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Sildenafil Citrate Therapy
Sildenafil Mechanism of Action
Sildenafil Citrate is a phosphodiesterase inhibitor that was originally
developed as an antianginal agent but was found to be more effective in
the treatment of impotence. It relaxes the arterial wall, leading to decreased
pulmonary arterial resistance and pressure. It also increases blood flow
to the penis. This mechanism of action does not directly cause penile
erections, but affects the response to sexual stimulation.
Flowing thru arteries, the blood in man's penis fills the spongy tissue
to cause an erection. Sometimes a health problem can withhold this mechanism
to works properly causing erectile dysfunction. Sildenafil Citrate works
by increasing blood flow to the penis, causing penile hardness and makes
to stay hard longer. It works in next 4 hours, only if you are sexually
aroused. After sex your erection will go away.
Sildenafil Therapy
As well as erectile dysfunction, sildenafil citrate is also effective
in the rare disease pulmonary arterial hypertension (PAH) therapy. The
Sildenafil therapy has not been approved for other, more common causes
of pulmonary hypertension, such as pulmonary hypertension related to left
heart disease (pulmonary venous hypertension), obstructive sleep apnea,
or chronic lung disease (chronic obstructive pulmonary disease, idiopathic
pulmonary fibrosis, etc.).
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